AT272530B - Verfahren zur Herstellung von neuen Thebain- und Oripavinderivaten - Google Patents
Verfahren zur Herstellung von neuen Thebain- und OripavinderivatenInfo
- Publication number
- AT272530B AT272530B AT571566A AT571566A AT272530B AT 272530 B AT272530 B AT 272530B AT 571566 A AT571566 A AT 571566A AT 571566 A AT571566 A AT 571566A AT 272530 B AT272530 B AT 272530B
- Authority
- AT
- Austria
- Prior art keywords
- oripavin
- thebaine
- derivatives
- new
- production
- Prior art date
Links
- ZKLXUUYLEHCAMF-UHFFFAOYSA-N Oripavine Chemical class COC1=CC=C2C(N(CC3)C)CC4=CC=C(O)C5=C4C23C1O5 ZKLXUUYLEHCAMF-UHFFFAOYSA-N 0.000 title 1
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 title 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 title 1
- 229930003945 thebaine Natural products 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB25289/65A GB1136214A (en) | 1965-06-15 | 1965-06-15 | Thebaine and oripavine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT272530B true AT272530B (de) | 1969-07-10 |
Family
ID=10225305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT571566A AT272530B (de) | 1965-06-15 | 1966-06-15 | Verfahren zur Herstellung von neuen Thebain- und Oripavinderivaten |
Country Status (14)
| Country | Link |
|---|---|
| AT (1) | AT272530B (en]) |
| BE (1) | BE682551A (en]) |
| BR (1) | BR6680359D0 (en]) |
| CH (1) | CH558362A (en]) |
| DE (1) | DE1620206A1 (en]) |
| DK (1) | DK115926B (en]) |
| ES (1) | ES327925A1 (en]) |
| FI (1) | FI49724C (en]) |
| FR (1) | FR6395M (en]) |
| GB (1) | GB1136214A (en]) |
| LU (1) | LU51306A1 (en]) |
| NL (1) | NL6608255A (en]) |
| NO (1) | NO119590B (en]) |
| SE (1) | SE325276B (en]) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2554816B1 (fr) * | 1983-11-16 | 1986-09-26 | Sanofi Sa | Nouveau derive de la nororipavine presentant a la fois une activite agoniste et antagoniste des recepteurs morphiniques |
| KR100204659B1 (ko) * | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| RU2138502C1 (ru) * | 1999-03-29 | 1999-09-27 | Закрытое акционерное общество "РМА-Фарм" | Способ получения 17-циклопропилметил-6,14-эндо-этано-7-(2-гидрокси-3,3-диметилбут-2-ил)тетр агидро-17-норорипавина |
| AUPQ968300A0 (en) | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
| GB2388369B (en) | 2002-05-10 | 2004-05-05 | Reckitt Benckiser Healthcare | Demethylation of thebaine derivative |
| GB0421687D0 (en) † | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| WO2006091885A2 (en) | 2005-02-24 | 2006-08-31 | Dr Pharma Nova, Llc | A registry method and control system for dea schedule ii-v medicines |
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| EP2326651B1 (en) * | 2008-07-30 | 2013-11-27 | Purdue Pharma LP | Buprenorphine analogs |
| CA2738758C (en) * | 2008-09-30 | 2016-11-29 | Mallinckrodt Inc. | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| NZ595591A (en) | 2009-04-24 | 2013-11-29 | Univ Brock | Processes for the preparation of morphinane and morphinone compounds |
| GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
| JP6289378B2 (ja) | 2011-12-12 | 2018-03-07 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ブプレノルフィンを含む経皮送達システム |
| EA034855B1 (ru) | 2012-07-26 | 2020-03-30 | Камурус Аб | Предшественник депо-препарата, содержащий бупренорфин, и способ лечения путем его введения |
| KR102098980B1 (ko) | 2012-07-26 | 2020-04-08 | 카무러스 에이비 | 오피오이드 제형 |
| JP6317755B2 (ja) * | 2012-12-07 | 2018-04-25 | パーデュー、ファーマ、リミテッド、パートナーシップ | オピオイド受容体モジュレーターとしてのブプレノルフィン類似体 |
| EP3106153A1 (en) | 2013-06-04 | 2016-12-21 | LTS LOHMANN Therapie-Systeme AG | Transdermal delivery system |
| WO2023111125A1 (en) | 2021-12-16 | 2023-06-22 | Arevipharma Gmbh | Method of making buprenorphine and precursor compounds thereof |
-
1965
- 1965-06-15 GB GB25289/65A patent/GB1136214A/en not_active Expired
-
1966
- 1966-06-10 NO NO163395A patent/NO119590B/no unknown
- 1966-06-13 FI FI661555A patent/FI49724C/fi active
- 1966-06-13 LU LU51306A patent/LU51306A1/xx unknown
- 1966-06-14 ES ES0327925A patent/ES327925A1/es not_active Expired
- 1966-06-14 BR BR180359/66A patent/BR6680359D0/pt unknown
- 1966-06-14 NL NL6608255A patent/NL6608255A/xx unknown
- 1966-06-14 SE SE08101/66A patent/SE325276B/xx unknown
- 1966-06-15 FR FR65560A patent/FR6395M/fr not_active Expired
- 1966-06-15 AT AT571566A patent/AT272530B/de active
- 1966-06-15 DK DK307766AA patent/DK115926B/da unknown
- 1966-06-15 CH CH861766A patent/CH558362A/de not_active IP Right Cessation
- 1966-06-15 DE DE19661620206 patent/DE1620206A1/de active Pending
- 1966-06-15 BE BE682551D patent/BE682551A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR6395M (en]) | 1968-10-21 |
| LU51306A1 (en]) | 1966-08-16 |
| CH558362A (de) | 1975-01-31 |
| SE325276B (en]) | 1970-06-29 |
| DK115926B (da) | 1969-11-24 |
| FI49724B (en]) | 1975-06-02 |
| FI49724C (fi) | 1975-09-10 |
| NL6608255A (en]) | 1966-12-16 |
| NO119590B (en]) | 1970-06-08 |
| BE682551A (en]) | 1966-11-14 |
| DE1620206A1 (de) | 1970-03-19 |
| BR6680359D0 (pt) | 1973-12-26 |
| ES327925A1 (es) | 1967-04-01 |
| GB1136214A (en) | 1968-12-11 |
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